Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review

October 2020 in “ Skin appendage disorders ”

Maira Elizabeth Herz-Ruelas, Neri Alejandro Álvarez-Villalobos, Juan Manuel Millán-Alanís, Humberto de Leon-Gutierrez, Jorge Ocampo-Candiani, Minerva Gómez-Flores, Ramon Grimalt

dutasteride oral dutasteride intralesional dutasteride androgenetic alopecia systemic treatment sexual adverse events Avodart

TLDR Oral dutasteride works better for hair loss, but has more sexual side effects; intralesional dutasteride is a possible alternative.

This systematic review analyzed the efficacy and safety of intralesional and oral dutasteride in treating androgenetic alopecia. The study found that both treatments were effective, but oral dutasteride appeared to be more effective than intralesional dutasteride. However, oral dutasteride had more reported sexual adverse events. Intralesional dutasteride may be a feasible alternative for those unwilling to receive systemic treatment, but more clinical trials evaluating its efficacy and safety are needed.

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13 / 13 results

research Prospective Randomized Study of Sexual Function in Men Taking Dutasteride for the Treatment of Androgenetic Alopecia

11 citations , April 2018 in “Journal of Dermatology”

Dutasteride safely treats hair loss without harming sexual function.

research Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia

32 citations , September 2016 in “Journal of Dermatology”

Dutasteride safely promotes hair growth and reduces hair loss, with mild side effects.

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , March 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Evaluation of the Effect of Injection of Dutasteride as a Mesotherapeutic Tool in the Treatment of Androgenetic Alopecia in Males

17 citations , January 2013 in “Our Dermatology Online”

Dutasteride mesotherapy helps treat male hair loss but may harm sperm and sexual function.

research S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents

151 citations , January 2011 in “British Journal of Dermatology”

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

research Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

92 citations , August 2010 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

research Medical Treatments for Male and Female Pattern Hair Loss

212 citations , October 2008 in “Journal of The American Academy of Dermatology”

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

research Dutasteride Improves Male Pattern Hair Loss in a Randomized Study in Identical Twins

39 citations , March 2007 in “Journal of Cosmetic Dermatology”

Dutasteride helps slow hair loss and boosts hair growth.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations , December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research The Genetics of Androgenetic Alopecia

50 citations , March 2001 in “Clinics in Dermatology”

Genes and hormones cause hair loss, with four genes contributing equally.

research Androgenetic Alopecia and Microinflammation

131 citations , August 2000 in “International Journal of Dermatology”

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

143 citations , October 1996 in “Dermatologic Clinics”

Too much androgen can cause hair loss; finasteride may help.

research Androgens and Human Hair Growth

157 citations , April 1994 in “Clinical endocrinology”

Androgens can cause hair growth in some areas and hair loss on the scalp.

10 / 10 results

research What's New in Therapy for Male Androgenetic Alopecia?

2 citations , September 2022 in “American Journal of Clinical Dermatology”

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

1 citations , August 2022 in “Journal of Dermatological Treatment”

research Combination Therapy with Oral Minoxidil and Dutasteride in the Treatment of Male Patterned Baldness: A Case Report

January 2022 in “Cosmoderma”

Using oral minoxidil and dutasteride together can quickly increase hair growth and volume with minimal side effects.

research Male Androgenetic Alopecia

100 citations , May 2010 in “Expert Opinion on Pharmacotherapy”

Hair loss in men treated best with early medication or transplant, new treatments researched.

research Effective Treatment of Female Androgenic Alopecia with Dutasteride

33 citations , September 2005 in “PubMed”

Dutasteride successfully treated a woman's hair loss when other treatments failed.

research Finasteride in the Treatment of Androgenetic Alopecia

62 citations , April 2004 in “Expert Opinion on Pharmacotherapy”

Finasteride effectively treats male pattern baldness, improving hair growth and density.

research Current Management of Androgenetic Alopecia in Men

4 citations , December 1999 in “PubMed”

Minoxidil and finasteride are promising drugs that can prevent hair loss and promote new growth in people with common hair loss condition.