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Glossary Peyronie's disease

condition causing curved, painful erections due to penile scar tissue

Peyronie's disease, also known as Induratio penis plastica (IPP), is a condition characterized by the development of fibrous scar tissue inside the penis, leading to curved, painful erections. This can result in difficulties with sexual intercourse and may be associated with erectile dysfunction. The exact cause is not well understood, but it is believed to involve trauma or injury to the penis, possibly combined with genetic factors.

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research Are finasteride-related penile curvature/Peyronie’s disease Adverse Event Reports worthy of further clinical investigation? Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases

2 citations , May 2022 in “International Journal of Impotence Research”

This pharmacovigilance study found strong disproportionality signals suggesting an association between finasteride and Peyronie's disease-related clinical features, but the evidence does not confirm a causal link.

research Trimodal Mini‐Invasive Therapy for Stable‐Phase Peyronie's Disease: A Two‐Center Real‐Life Prospective Pilot Study

January 2026 in “Andrology”

This study found that PRP injections are safe and may slightly reduce penile curvature and improve PDQ scores in men with stable-phase Peyronie's Disease, but the changes are not significant enough to predict long-term effects.

Trimodal Minimally Invasive Therapy for Stable-Phase Peyronie's Disease: A Two-Center Real-Life Prospective Pilot Study

research Trimodal mini-invasive therapy for stable-phase Peyronie's disease: a two-center real-life prospective pilot study

September 2025

This study found that PRP injections may safely improve penile curvature and PDQ scores in men with stable-phase Peyronie's Disease, although the curvature reduction observed was not enough to determine long-term clinical significance.

Evaluation of Intralesional Injection of Platelet-Derived Growth Factors in Patients With Peyronie's Disease

research Evaluation of intralesional injection of platelet derived growth factors PDGF ma in patients with Peyronie's disease

May 2025

This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.

research Is finasteride intake associated with penile curvature/peyronie’s disease? Assessment of both the food and drug administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases

October 2021 in “European urology open science”

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community Side effects of topical azelaic acid?

4 upvotes 5 years ago

Azelaic acid is considered a strong DHT inhibitor with no reported sexual side effects, making it a potential alternative for those who cannot use finasteride. It can be used with minoxidil, but may cause skin irritation.

community Microneedling with Verteporfin

3 upvotes 4 years ago

community Should I risk changing to Dutasteride?

in Finasteride/Dutasteride 10 upvotes 1 year ago

The user is considering switching from Finasteride to Dutasteride for better hair regrowth, despite concerns about potential shedding and side effects. Opinions vary, with some suggesting the switch for stronger results and others advising caution due to possible side effects and the importance of consulting a doctor.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Pirfenidone - The answer to fibrosis and baldness

20 upvotes 4 years ago

Pirfenidone is suggested to treat fibrosis and baldness by blocking inflammation markers and reducing collagen. It is also available as a gel for scar removal.

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