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GlossaryPeyronie's disease

condition causing curved, painful erections due to penile scar tissue

Peyronie's disease, also known as Induratio penis plastica (IPP), is a condition characterized by the development of fibrous scar tissue inside the penis, leading to curved, painful erections. This can result in difficulties with sexual intercourse and may be associated with erectile dysfunction. The exact cause is not well understood, but it is believed to involve trauma or injury to the penis, possibly combined with genetic factors.

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research Are Finasteride-Related Penile Curvature/Peyronie’s Disease Adverse Event Reports Worthy of Further Clinical Investigation? Disproportionality Analysis Based on Both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Pharmacovigilance Databases

2 citations, May 2022 in “International Journal of Impotence Research”

Finasteride may be linked to Peyronie’s disease, but more research is needed.

research Finasteride-Related Peyronie's Disease

May 2022 in “Reactions Weekly”

research Is Finasteride Intake Associated with Penile Curvature/Peyronie’s Disease? Assessment of Both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Pharmacovigilance Databases

October 2021 in “European urology open science”

research Post-Finasteride Syndrome: An Underestimated Phenomenon

May 2017 in “Urology and andrology”

Finasteride and dutasteride, used for prostate issues and hair loss, can cause side effects like sexual dysfunction and mental issues, which may continue even after stopping the medication, a condition called post-finasteride syndrome, for which there's currently no cure.

research Topical Minoxidil in the Treatment of Male Erectile Dysfunction

28 citations, May 1994 in “The Journal of Urology”

Topical minoxidil not effective for erectile dysfunction treatment.

research The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies

11 citations, June 2018 in “Sexual medicine reviews”

Stromal Vascular Fraction might help with male sexual dysfunction, but more research is needed to confirm its safety and effectiveness.

Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024

research Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024

August 2024 in “medRxiv (Cold Spring Harbor Laboratory)”

Finasteride has various adverse effects, including sexual dysfunction and mental health issues, which vary by age and gender.

research Reinventing the Selfie: Telemedicine in a Tertiary Referral Sexual Medicine Practice

February 2018 in “The journal of sexual medicine”

Telemedicine is effective for sexual medicine consultations.

research Platelet-Rich Plasma for Urologic Conditions: An Early Call for Composition Reporting

November 2023 in “The Journal of Urology”

The conclusion is that future trials should report specific details about the PRP composition to better understand its effects on urologic conditions.

research Cutaneous Side-Effects of Beta-Adrenergic Blockers

22 citations, April 1985 in “Australasian Journal of Dermatology”

Beta-blockers can cause rare skin side-effects, which usually improve after stopping the medication.

research Immunologic Adverse Reactions of Beta-Blockers and the Skin: A Review

31 citations, April 2019 in “Experimental and Therapeutic Medicine”

β-blockers can cause skin problems like psoriasis and vitiligo, and doctors should tell patients about these risks.

research The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction

21 citations, July 2018 in “The Journal of Sexual Medicine”

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.

research Anti-Anginal and Beta-Adrenoceptor Blocking Drugs

January 1983 in “Side effects of drugs annual”

Beta-blockers and anti-anginal medications have various side effects and interactions that require careful monitoring and individualized treatment.

research Utilization of Telemedicine in the U.S. Military in a Deployed Setting

33 citations, November 2014 in “Military Medicine”

The U.S. military's teledermatology program was effective in providing fast and successful skin care in remote locations, preventing unnecessary evacuations.

research The Conception and Evaluation of Sexual Health Literature

3 citations, December 2016 in “Sexual medicine reviews”

The document concludes that better research methods are needed in men's sexual health to provide stronger evidence and improve patient care.

research Adipose-Derived Stromal Cells in Regenerative Medicine: A Review

76 citations, January 2017 in “World Journal of Stem Cells”

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

research Erectile Dysfunction in Young Men: A Review of Prevalence and Risk Factors

176 citations, June 2017 in “Sexual Medicine Reviews”

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

research Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

33 citations, January 2016 in “Skin appendage disorders”

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

research Introduction

January 2020 in “Fertility and Sterility”

The conclusion is that it's currently unclear if certain rare medical conditions are caused by specific factors due to mostly observational data.

research Case Study: The Sexual, Physical, and Psychological Effects of Post-Finasteride Syndrome

October 2024 in “Journal of the Endocrine Society”

Post-finasteride syndrome can cause lasting sexual, physical, and mental health issues with limited treatment options.

Oral Presentations: Abstracts of the Urological Society of Australia and New Zealand Annual Scientific Meeting, Melbourne, Australia

research Oral Presentations: Abstracts of the Urological Society of Australia and New Zealand Annual Scientific Meeting, Melbourne, Australia

2 citations, February 2023 in “BJUI”

Urologists should monitor mental health in patients taking finasteride due to potential links to suicidal thoughts, adjusting dosage or stopping use if necessary. More research is needed to confirm if finasteride causes these thoughts.

research Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

81 citations, June 2014 in “American Journal of Men's Health”

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

research Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

9 citations, January 2018 in “American Journal of Men's Health”

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.

research Post Finasteride Syndrome: Is Dutasteride Unfairly Accused?

May 2016 in “The Journal of Sexual Medicine”

research Sexual Dysfunction in Men Taking Systemic Dermatologic Medication: A Systematic Review

11 citations, March 2019 in “Journal of The American Academy of Dermatology”

Some men taking finasteride for hair loss may experience sexual problems like erectile dysfunction and decreased sex drive, which can persist even after stopping the medication.