Maculopapular Drug Eruption Caused by Finasteride: A Case Report

    November 2023 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Hongxia Jia, Liwei Ran
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    TLDR A man's rash caused by Finasteride improved after stopping the drug and starting new treatments.
    A 76-year-old male developed a maculopapular rash on his trunk and extremities two months after starting Finasteride treatment for prostatic hyperplasia. Despite treatment with antihistamines and glucocorticoids, there was no significant improvement. The patient was diagnosed with a maculopapular drug eruption caused by Finasteride. After discontinuing Finasteride and starting treatment with ebastine tablets, halometasone cream, and zinc oxide ointment, the patient's condition improved significantly with no recurrence observed during a 1-year follow-up. This case suggests that if apoptotic keratinocytes, eosinophilia, and periappendicular inflammatory cell infiltration are visible in the histopathology, it is necessary to be alert to drug causation. For patients with prostatic hyperplasia who have a drug eruption caused by Finasteride, Tamsulosin hydrochloride or Celodosinto can be considered as alternative therapies.
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