Association of 5α-Reductase Inhibitors With Depression and Suicide: A Mini Systematic Review and Meta-Analysis

    May 2024 in “ European urology focus ”
    Alessandro Uleri, Jean Nicolas Cornu, Andrea Gobbo, Thomas Herrmann, Cosimo De Nunzio, Hashim Hashim, Michael Baboudjian
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    TLDR Drugs for prostate enlargement and hair loss were not linked to increased risk of depression or suicide.
    A systematic review and meta-analysis of five studies involving 2,213,600 patients was conducted to investigate the potential risks of depression and suicide associated with 5α-Reductase inhibitors (5-ARIs), drugs commonly prescribed for benign prostatic obstruction and androgenic alopecia. The analysis found no statistically significant association between 5-ARI exposure and the risk of depression (adjusted hazard ratio [aHR] 1.30, 95% confidence interval [CI] 0.85–2.00; p = 0.23) or suicide (aHR 1.30, 95% CI 0.65–2.61; p = 0.45). Similar results were observed in subgroup analyses for finasteride and dutasteride, and when the analysis was restricted to patients without a prior diagnosis of depression.
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