5α-Reductase Inhibitors: Evaluation of Their Potential Confounding Effect on GC-C-IRMS Doping Analysis

    July 2021 in “ Drug Testing and Analysis ”
    Loredana Iannella, Cristiana Colamonici, Davide Curcio, Francesco Botrè, Xavier de la Torre
    Image of study
    TLDR 5α-reductase inhibitors can interfere with doping tests by masking banned substances.
    The study examined the effects of 5α-reductase inhibitors (5-ARIs), particularly finasteride, on the carbon isotopic composition of testosterone and nandrolone metabolites in doping analysis. Analyzing urine samples from three male volunteers after both acute and chronic finasteride administration, the results indicated that finasteride significantly alters the enzymatic pathways and isotopic profiles of these metabolites. This suggests that 5-ARIs can confound doping tests by masking the presence of banned substances like nandrolone, highlighting the need for careful monitoring to avoid misinterpretation in doping analyses.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 101 results

      community Nandrolone Replacement Therapy

      in Treatment  41 upvotes 1 year ago
      A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  73 upvotes 4 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community DHT/Testosterone levels in scalp Fin VS Dut.

      in Finasteride/Dutasteride  66 upvotes 7 months ago
      Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 1 year ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

    Related Research

    1 / 1 results