5α-Reductase Inhibitors: Evaluation of Their Potential Confounding Effect on GC-C-IRMS Doping Analysis

    July 2021 in “ Drug Testing and Analysis ”
    Loredana Iannella, Cristiana Colamonici, Davide Curcio … Xavier de la Torre
    Studysummary This study found that chronic administration of finasteride affected the isotopic composition of testosterone and nandrolone metabolites, impacting the drug-testing outcomes in athletic contexts.
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    Research cited in this study 8

    1. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    2. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    3. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013
    4. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    5. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    6. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    7. Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite Therapeutic Drug Monitoring · 2007
    8. Dermatology of Androgen-Related Disorders Clinics in Dermatology · 2006

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    1. 5α-Reductase Inhibitors: Evaluation of Their Potential Confounding Effect on GC-C-IRMS Doping Analysis Drug Testing and Analysis · 2021