Induction of Hyperandrogenism and Insulin Resistance Differentially Modulates Ferroptosis in Uterine and Placental Tissues of Pregnant Rats

    March 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Yuehui Zhang, Min Hu, Wenyan Jia, Guoqi Liu, Jiao Zhang, Bing Wang, Juan Li, Peng Cui, Xin Li, Susanne Lager, Amanda N. Sferruzzi‐Perri, Yanhua Han, Songjiang Liu, Xiaoke Wu, Mats Brännström, Ruijin Shao, Håkan Billig
    Image of study
    TLDR HAIR may cause fetal loss by triggering different cell death processes in the uterus and placenta.
    The study investigated the effects of hyperandrogenism and insulin resistance (HAIR) on ferroptosis in the uterine and placental tissues of pregnant rats, simulating conditions similar to polycystic ovary syndrome (PCOS) in humans. It found that HAIR led to increased fetal loss, with the uterus showing decreased levels of Gpx4 and glutathione (GSH), increased oxidative stress markers, and changes in ferroptosis-associated gene expression, indicating activation of ferroptosis. In contrast, the placenta showed only partial changes in ferroptosis markers. The study concluded that HAIR-induced ferroptosis in the uterus and placenta might contribute to fetal loss, with different molecular mechanisms involved in each tissue, and suggested that other cell death pathways, such as necroptosis and apoptosis, might also play roles in this process.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 9 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  6 upvotes 2 years ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Balding without a family history

      in Chat  6 upvotes 1 week ago
      The user is experiencing hair loss without a family history and suspects stress or telogen effluvium (TE) as the cause, despite using finasteride without results. Others suggest stress, vitamin deficiencies, or other conditions could be factors, and some mention that balding can occur without a family history.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 3 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

    Related Research

    4 / 4 results