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research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations , December 2015 in “Journal of Investigative Dermatology”

This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations , March 2024 in “International journal of molecular sciences”

This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.

research 1341 Possible role of mTOR signaling pathway in radiation dermatitis

April 2023 in “Journal of Investigative Dermatology”

This study suggests that the mTOR signaling pathway may play a role in the pathophysiology of radiation dermatitis, with expression patterns of S6K1 protein differing from those in normal and inflamed skin.

research Prevention and correction of radiation dermatitis with basic skin care: doctor and patient consensus

December 2021 in “Meditsinskiy sovet = Medical Council”

This case study describes the experience of using dermatocosmetic products to manage radiation dermatitis in a patient, but it reports no new clinical results.

research Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis

61 citations , April 2014 in “Radiation Research”

This study observed that topically applied RTA 408 reduced the severity of radiation-induced dermatitis in mice, with the highest dose significantly reducing and alleviating skin damage and associated inflammation.

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community Lots of shedding after adding bica 50 mg daily

in Transgender 119 upvotes 1 year ago

Switching from spironolactone to bicalutamide caused severe hair shedding, despite using treatments like dutasteride, minoxidil, and estradiol injections. The user is experiencing androgenetic alopecia and is seeking solutions to stop the hair loss.

community Losing the gains and frontline of battle

in Progress Pictures 59 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically the use of dutasteride, finasteride, and other methods like PRP, laser, and mesotherapy. Despite these treatments, the user is experiencing hair loss, and others suggest consulting a dermatologist, considering alternative treatments, and addressing potential scalp inflammation.

community My finasteride progress in a 6 month

1282 upvotes 8 months ago

Successful hair regrowth after six months using finasteride and topical minoxidil, with minimal side effects like anxiety. Finasteride was the main treatment, and minoxidil supported regrowth.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community 6 Months Into Dut Progress Pictures

102 upvotes 1 year ago

Switching from finasteride to dutasteride caused significant shedding but minimal side effects. The user plans to continue dutasteride for 12 months despite concerns about hair density.

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