Reduced SMAD2/3 Activation Independently Predicts Increased Depth of Human Cutaneous Squamous Cell Carcinoma

    February 2018 in “ Oncotarget ”
    Aidan M. Rose, Lindsay C. Spender, Christopher D. Stephen … Gareth J. Inman
    Studysummary This study observed that reduced activation of SMAD2/3 proteins in cutaneous squamous cell carcinoma tissue compared to adjacent tissue may indicate a tumor suppressor role in disease progression.
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    Research cited in this study 6

    1. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016
    2. The Dynamic Duo: Niche and Stem Cell Interdependency Stem Cell Reports · 2015
    3. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    4. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    5. The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function Cytokine & Growth Factor Reviews · 2008
    6. Conditional Epidermal Expression of TGFβ1 Blocks Neonatal Lethality but Causes a Reversible Hyperplasia and Alopecia Proceedings of the National Academy of Sciences · 2001