Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

April 2020 in “ International Journal of Dermatology and Venereology ”

Qun Lv, Yun Ye, Liming Li, Fengjuan Li, Yi‐Lin Wu, Mingjun Jiang

beta human papillomavirus Merkel cell polyomavirus skin neoplasms nonmelanoma squamous carcinoma Merkel cell carcinoma beta-HPV immunocompromised carcinogenesis viral antigens tumor maintenance viral oncogenic proteins vaccines HPV MCPyV skin cancer squamous cell carcinoma Merkel cell cancer

TLDR Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.

The document reviewed the roles of beta human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in skin neoplasms, focusing on nonmelanoma squamous carcinoma and Merkel cell carcinoma. Beta-HPVs, particularly types 5, 8, and 38, were implicated in skin carcinogenesis, especially in immunocompromised individuals, through mechanisms like the "hit-and-run" hypothesis. MCPyV was associated with Merkel cell carcinoma, requiring continuous expression of viral antigens for tumor maintenance. The study emphasized the need for further research into the molecular mechanisms and interactions of these viruses in skin cancer development and highlighted the potential for new therapies targeting viral oncogenic proteins. Vaccines for beta-HPV and MCPyV were still under development.

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research Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

2 citations, April 2020 in “International Journal of Dermatology and Venereology”

Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.