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GlossaryMerkel cell polyomavirus

virus linked to rare skin cancer, Merkel cell carcinoma

Merkel cell polyomavirus (MCV or MCPyV) is a virus that has been linked to a rare and aggressive form of skin cancer known as Merkel cell carcinoma. Discovered in 2008, this virus is found in the majority of Merkel cell carcinoma tumors, suggesting a strong association between the virus and the development of this cancer.

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research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations , February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Near Missed Diagnosis of Merkel Cell Carcinoma in a Young Immunocompetent Woman With a Recurrent Left-Arm Mass: A Case Report

April 2023 in “Authorea (Authorea)”

A young woman with a rare skin cancer was diagnosed late because her symptoms were unusual for the disease.

research Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

2 citations , April 2020 in “International Journal of Dermatology and Venereology”

Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Merkel Cell Polyomavirus Infection And Persistence Modeled In Skin Organoids

2 citations , February 2025

Merkel cell polyomavirus can infect and persist in skin cells, evading the immune system, but certain treatments can control it.

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