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GlossaryMerkel cell polyomavirus

virus linked to rare skin cancer, Merkel cell carcinoma

Merkel cell polyomavirus (MCV or MCPyV) is a virus that has been linked to a rare and aggressive form of skin cancer known as Merkel cell carcinoma. Discovered in 2008, this virus is found in the majority of Merkel cell carcinoma tumors, suggesting a strong association between the virus and the development of this cancer.

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research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations, May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Transduction-Induced Overexpression of Merkel Cell T Antigens in Human Hair Follicles Induces Formation of Pathological Cell Clusters with Merkel Cell Carcinoma-Like Phenotype

5 citations, August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

research Near Missed Diagnosis of Merkel Cell Carcinoma in a Young Immunocompetent Woman With a Recurrent Left-Arm Mass: A Case Report

April 2023 in “Authorea (Authorea)”

A young woman with a rare skin cancer was diagnosed late because her symptoms were unusual for the disease.

research Molecular Mechanisms of Viral Oncogenesis in Humans

141 citations, August 2018 in “Nature Reviews Microbiology”

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

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