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GlossaryMerkel cell carcinoma

rare, aggressive skin cancer originating from touch-sensing Merkel cells

Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer that originates from Merkel cells, which are found at the base of the epidermis and are involved in the sense of touch. This type of cancer often appears as a fast-growing, painless nodule on sun-exposed areas of the skin, such as the face, neck, and arms. Early detection and treatment are crucial due to its high potential for metastasis.

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research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Transduction-Induced Overexpression of Merkel Cell T Antigens in Human Hair Follicles Induces Formation of Pathological Cell Clusters with Merkel Cell Carcinoma-Like Phenotype

5 citations, August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

Risk of Merkel Cell Carcinoma Progression After Treatment Discontinuation in Patients With an Objective Response to Anti-PD-(L)1 Immunotherapy

research Risk of Merkel Cell Carcinoma Progression After Treatment Discontinuation in Patients With an Objective Response to Anti-PD-(L)1 Immunotherapy

August 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Longer immunotherapy treatment may improve outcomes for Merkel cell carcinoma patients.

research Near Missed Diagnosis of Merkel Cell Carcinoma in a Young Immunocompetent Woman With a Recurrent Left-Arm Mass: A Case Report

April 2023 in “Authorea (Authorea)”

A young woman with a rare skin cancer was diagnosed late because her symptoms were unusual for the disease.

Addressing the Missing Components for Appropriate Surveillance of Merkel Cell Carcinoma Patients: Detailed Recurrence Data and an Integrated Risk Analysis Approach

research Addressing the Missing Components for Appropriate Surveillance of Merkel Cell Carcinoma Patients: Detailed Recurrence Data and an Integrated Risk Analysis Approach

April 2019 in “Journal of Investigative Dermatology”

Merkel cell carcinoma is most likely to recur within two years of diagnosis, and factors like immune suppression, being over 75, and male sex increase this risk.

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