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GlossaryMerkel cells

specialized skin cells that detect touch and pressure

Merkel cells are specialized skin cells located in the epidermis, particularly in areas with high tactile sensitivity like fingertips. They function as mechanoreceptors, meaning they help detect touch and pressure, and are connected to nerve endings to transmit sensory information to the brain.

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research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice

14 citations, February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Transduction-Induced Overexpression of Merkel Cell T Antigens in Human Hair Follicles Induces Formation of Pathological Cell Clusters with Merkel Cell Carcinoma-Like Phenotype

5 citations, August 2021 in “Experimental dermatology”

Overexpressing Merkel cell virus proteins in human hair follicles can create clusters of cells that resemble Merkel cell cancer.

Risk of Merkel Cell Carcinoma Progression After Treatment Discontinuation in Patients With an Objective Response to Anti-PD-(L)1 Immunotherapy

research Risk of Merkel Cell Carcinoma Progression After Treatment Discontinuation in Patients With an Objective Response to Anti-PD-(L)1 Immunotherapy

August 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Longer immunotherapy treatment may improve outcomes for Merkel cell carcinoma patients.

research Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers

438 citations, October 2010 in “Oncogene”

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers

7 citations, August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

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in Research/Science 10 months ago

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in Research/Science 119 upvotes 9 months ago

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