Grp1-Associated Scaffold Protein Regulates Skin Homeostasis After Ultraviolet Irradiation

The study found that Grasp, a protein induced by retinoic acid, was expressed in mouse skin and significantly increased after UVB exposure. Grasp(-/-) mice showed delayed skin cell proliferation and reduced apoptosis following UVB exposure. Additionally, the tumor suppressor protein p53 had a shorter nuclear residence time in these mice. These findings suggested that Grasp played a role in regulating skin homeostasis after UVB exposure, possibly by affecting p53-mediated apoptotic responses.