Grp1-Associated Scaffold Protein Regulates Skin Homeostasis After Ultraviolet Irradiation

March 2014 in “ Photochemical & photobiological sciences ”

Anand Venkataraman, Daniel J. Coleman, Daniel J. Nevrivy, Tulley Long, Chrissa Kioussi, Arup K. Indra, Mark Leid

Grp1-associated scaffold protein Grasp retinoic acid UVB exposure skin cell proliferation apoptosis tumor suppressor protein p53 skin homeostasis UVB

TLDR Grasp protein helps maintain skin health after UVB exposure.

The study found that Grasp, a protein induced by retinoic acid, was expressed in mouse skin and significantly increased after UVB exposure. Grasp(-/-) mice showed delayed skin cell proliferation and reduced apoptosis following UVB exposure. Additionally, the tumor suppressor protein p53 had a shorter nuclear residence time in these mice. These findings suggested that Grasp played a role in regulating skin homeostasis after UVB exposure, possibly by affecting p53-mediated apoptotic responses.

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Grp1-Associated Scaffold Protein Regulates Skin Homeostasis After Ultraviolet Irradiation

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