Enhancement of Hair Growth Through Stimulation of Hair Follicle Stem Cells by Prostaglandin E2 Collagen Matrix

December 2022 in “ Experimental cell research ”

Hui Cheng, Fei Liu, Manqian Zhou, Shang Chen, Huang Hu, Yue Liu, Xiaotong Zhao, Qiaonan Zhang, Xinrun Zhou, Zongjin Li, Hong Cai

prostaglandin E2 PGE2 collagen matrix hair follicle stem cells Sox9 Lgr5 anagen phase hair follicle growth collagen

TLDR Prostaglandin E2 collagen matrix may help stimulate hair growth.

The study investigated the effects of a prostaglandin E2 (PGE2) collagen matrix on hair growth. By conjugating PGE2 with collagen to prevent rapid degradation, researchers applied this matrix to a mouse model of hair loss. The results showed that the PGE2 matrix increased the proportion of hair follicles in the early anagen phase and upregulated hair follicle stem cell markers Sox9 and Lgr5, indicating enhanced hair follicle growth. This suggests that the PGE2 matrix could be a promising therapeutic strategy for treating hair disorders.

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