HMGB1 Promotes Hair Growth via the Modulation of Prostaglandin Metabolism

    April 2019 in “ Scientific Reports ”
    Jin Soo Hwang, Howard Chu, Young Soo Ahn … Doyoung Kim
    Studysummary This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.
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    Research cited in this study 10

    1. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    2. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    3. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    4. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    5. Prostaglandin Metabolism in Human Hair Follicle Experimental Dermatology · 2007
    6. UV Light May Induce Hypertrichosis Through Production of Prostaglandin E2 Medical hypotheses · 2006
    7. Paradoxical Hypertrichosis After Laser Epilation Journal of The American Academy of Dermatology · 2005
    8. Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model Experimental dermatology · 2005
    9. Prostaglandin-Induced Hair Growth Survey of Ophthalmology · 2002
    10. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997