Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia

    December 2023
    Ji Li, Xuening Duan, Fan Cheng, Li Guo, Zhili Deng, Yang Li, Jin Zhang, Fen Liu, Yun Li, Zhaohe Wu, Mengting Chen, Ben Wang, Xingguang Zhao, Wei Shi, Fenlong Xie, Yan Tang
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    TLDR Problems with arginine processing in hair follicles might contribute to common hair loss, and arginine supplements could help treat it.
    The study "Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia" found a significant decrease in serum abundance of arginine in patients with Androgenetic Alopecia (AGA), a common hair loss disorder. The researchers observed impaired arginine metabolism in the hair follicles of these patients, indicated by increased expression of ARG1, an enzyme regulating arginine-ornithine transition, and decreased expression of the arginine transporter SLC7A1. The study also showed that arginine deficiency hinders hair growth by antagonizing the mTOR signaling pathway. However, administering arginine effectively protected against hair growth inhibition in an AGA-like mouse model and in balding hair follicles from AGA patients. This suggests that arginine supplementation could be a potential treatment strategy for AGA.
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