research Single-Cell Protein Activity Inference Analysis of Full-Thickness Skin Uncovers Novel Pathways and a Rare Arg1+ Macrophage Population in Alopecia Areata
Arg1+ macrophages may play a role in Alopecia Areata, offering new treatment targets.
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5 / 156 resultsresearch Single Cell Transcriptomics Identifies a Potential Role for Arg1+ Macrophages in Alopecia Areata Pathogenesis
This study investigated the role of immune cells in Alopecia Areata (AA) by performing single cell RNA-seq on CD45+ immune cells from AA-affected and control mice. It identified a unique subset of Arg1+ macrophages predominantly present in AA mice, suggesting their involvement in AA pathogenesis. These macrophages showed upregulation of genes related to arginine metabolism and pro-inflammatory cytokines, indicating an inflammatory phenotype. Validation techniques confirmed an increased presence of Arg1+ macrophages near hair follicles in AA skin. Treatment with an arginase inhibitor delayed disease onset in mice, highlighting potential therapeutic targets in metabolic pathways for AA.
research Type A Insulin Resistance Syndrome Due to a Novel Heterozygous c.3486_3503del (p. Arg1163_Ala1168del) INSR Gene Mutation in an Adolescent Girl and Her Mother
A new gene mutation causes insulin resistance in a girl and her mother.
research Case Report of Schöpf–Schulz–Passarge Syndrome Resulting from a Missense Mutation, p.Arg104Cys, in WNT10A
A new gene mutation caused a man's rare skin condition, Schöpf-Schulz-Passarge syndrome.
research NUDT15, FTO, and RUNX1 Genetic Variants and Thiopurine Intolerance Among Japanese Patients With Inflammatory Bowel Diseases
Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.
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