Single-Cell Protein Activity Inference Analysis of Full-Thickness Skin Uncovers Novel Pathways and a Rare Arg1+ Macrophage Population in Alopecia Areata

July 2022 in “ Journal of Investigative Dermatology ”

E.Y. Lee, A. Obradovic, E. Wang, A.M. Christiano

New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide →

Alopecia Areata single-cell RNA sequencing keratinocyte MHC Class II necroptosis hair follicle Arg1+ macrophages arginine metabolism pro-inflammatory cytokines arginase inhibitor nor-NOHA AA Arg1 MHC II

Studysummary Arg1+ macrophages may play a role in Alopecia Areata, offering new treatment targets.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on jidonline.org →

Discuss this study in the Community →

Related Research

4 / 4 results

research LB789 Novel IFNγ Aptamer TAGX-0003 Protected Hair Follicles from Immune Privilege Collapse and Reversed Alopecia Areata-Like Phenotype in Humanized Mouse Model

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews current treatments for alopecia areata, discussing the potential role of JAK inhibitors and noting the need for further clinical trials, but it reports no new results.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations , July 2020 in “Experimental dermatology”

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

research Gamma Delta T Cells as Novel Players in Alopecia Areata Pathobiology: Vdelta1 Positive T Lymphocytes May Recognize Stressed Hair Follicle Keratinocytes, Leading to IFN Gamma-Dependent Hair Follicle Dystrophy and Immune Privilege Collapse

1 citations , April 2016 in “Journal of Investigative Dermatology”

This study suggests that NKG2D+ Vδ1 T cells may contribute to hair follicle pathology in alopecia areata by recognizing stressed keratinocytes and inducing immune privilege collapse.

research Mathematical Model for Alopecia Areata

6 citations , June 2015 in “Journal of theoretical biology”

This study suggests that immune privilege guardians and the pro-inflammatory cytokine interferon-γ significantly influence the dynamics of alopecia areata, supporting the hypothesis that immune privilege collapse is crucial in its development.