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GlossaryMHC Class II (MHC II)

molecules on immune cells presenting antigens to T-helper cells

MHC Class II, or Major Histocompatibility Complex Class II, are molecules found on the surface of certain immune cells, such as dendritic cells, macrophages, and B cells. They play a crucial role in the immune system by presenting foreign antigens to T-helper cells, which then activate other immune responses to fight off infections.

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research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations, January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

research The Function and Structure of the Skin

4 citations, November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

research Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

TYK2 inhibition may help treat alopecia areata by promoting hair growth and reducing immune response.

research Selective Inhibition of Tyrosine Kinase 2 Prevents and Restores Interleukin-12-Induced Hair Follicle Immune Privilege Collapse: A Novel Approach to Alopecia Areata Therapy?

October 2021 in “Journal of Investigative Dermatology”

Blocking IL-12 can help treat alopecia areata by preventing hair follicle immune issues.

research Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege

47 citations, December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

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