Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

February 2022 in “ Biological Trace Element Research ”

Betül Demir, Demet Çiçek, Cemal Orhan, Beşir Er, Füsun Erten, Mehmet Tuzcu, İbrahim Hanifi Ozercan, Nurhan Şahin, James Komorowski, Sara Perez Ojalvo, Sarah Sylla, Kazım Şahin

Arginine Silicate Inositol Complex Biotin hair density growth phase resting phase hair follicle formation hair follicle regeneration alopecia growth factors ASI MgB

TLDR The combination of Arginine Silicate Inositol Complex and a new form of Biotin improved hair and nail growth in rats.

The study involved 28 rats and examined the effects of Arginine Silicate Inositol Complex (ASI) and a novel form of Biotin (MgB) on hair and nail growth. The results showed that the combination of ASI and MgB significantly increased hair density and the percentage of hair in the growth phase, while decreasing the percentage of hair in the resting phase. The group receiving the highest dose of MgB showed a 55% increase in hair density and a 48.66% increase in the growth phase. This group also showed significant nail growth. Molecular analysis revealed increased levels of growth factors and signals crucial for hair follicle formation and regeneration. The study concluded that the combination of ASI and MgB promotes hair and nail growth, potentially offering a new approach for treating conditions like alopecia.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research The Role of Vitamins and Minerals in Hair Loss: A Review

134 citations , December 2018 in “Dermatology and Therapy”

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research A Review of the Use of Biotin for Hair Loss

78 citations , January 2017 in “Skin appendage disorders”

Biotin supplements may improve hair and nail growth in people with certain deficiencies or conditions, but there's not enough evidence to recommend it for healthy individuals.

Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia

research Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia

17 citations , October 2016 in “Artificial Cells Nanomedicine and Biotechnology”

Using tiny fat particles to deliver arginine to hair follicles could be a new way to treat hair loss.

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.

research Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin

32 citations , June 2015 in “PLOS ONE”

Olive leaf compound oleuropein helps grow hair in mice.

research Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-β Expression.

26 citations , January 2015 in “PubMed”

Collagenase IV helps control hair growth by affecting certain growth factors.

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

research Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia

27 citations , February 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Diffuse Hair Loss: Its Triggers and Management

88 citations , June 2009 in “Cleveland Clinic Journal of Medicine”

To manage diffuse hair loss, identify the cause, improve nutrition, remove triggers, and use specific treatments like minoxidil or finasteride.

research A Cell-Based System for Screening Hair Growth-Promoting Agents

39 citations , March 2009 in “Archives of Dermatological Research”

Apigenin may help promote hair growth and could treat hair loss.

research Biotin And Biotinidase Deficiency

166 citations , November 2008 in “Expert Review of Endocrinology & Metabolism”

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

research Hepatocyte Growth Factor Activator Expressed in Hair Follicles Is Involved in In Vitro HGF-Dependent Hair Follicle Elongation

77 citations , February 2001 in “Journal of Dermatological Science”

HGF activator helps convert HGF to its active form, promoting hair growth.

Similar Research

5 / 809 results

research Insulin-Like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential

September 2025 in “Current Issues in Molecular Biology”

IGF-1 can help regrow hair and may be a promising treatment for hair loss.

research The Effect of a Combination of an Arginine Silicate Complex and Magnesium Biotinate on Hair and Nail Growth in Rats

1 citations , June 2019 in “Current developments in nutrition”

A combination of arginine silicate complex and magnesium biotinate improves hair and nail growth in rats.

research Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study

April 2024 in “Current research in nutrition and food science”

Taking an amino acid supplement improved skin, hair, and nail health in women.

Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia

research Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia

August 2025 in “PubMed”

Arginine deficiency hinders hair growth in androgenetic alopecia, but restoring it can promote hair regeneration.

research An Open-Label Experience Trial to Evaluate the Effects of a Novel Supplement and Hair Serum Combination on Hair, Skin, and Nails in Healthy Women

June 2021 in “Current developments in nutrition”

The LustrivaTM BH-002 supplement and hair serum improved women's hair, skin, and nail health and appearance.