Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study

April 2024 in “ Current research in nutrition and food science ”

Vincenzo Nobile, Enza Cestone, Marta Pisati, Gloria Roveda

amino acids Glycine L-Alanine L-Proline L-Valine L-Leucine L-Lysine telogen hair hair density hair loss shedding phase

From the encyclopedia

Studysummary This study found that a food supplement improved skin moisturization, elasticity, and thickness, reduced telogen hair density, and enhanced nail status in women with mild-to-moderate aging signs after 84 days. Our plain-language summary of this paper — not a Tressless recommendation.

The study involved 21 healthy Caucasian females aged between 35 and 70, who took an oral supplement containing a mixture of amino acids (Glycine, L-Alanine, L-Proline, L-Valine, L-Leucine, L-Lysine) for 84 days. The supplement significantly reduced wrinkle depth by 14.5%, improved skin smoothness by 7.7%, increased superficial skin moisturization by 9.2%, deep skin moisturization by 7.6%, skin elasticity by 11.9%, and skin thickness by 0.24 mm. Hair density improved with a 9.5% decrease in telogen hair (shedding phase), and hair loss was reduced with the total number of hair plucked decreasing to 6.3. Nail conditions improved in 62-67% of subjects, showing increased hardness, smoothness, evenness, and hydration. The supplement was well tolerated with no reported adverse reactions, suggesting that the tested amino acid mixture can improve skin, hair, and nail health.

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