Efficacy and Tolerability of an Oral Supplement Containing Amino Acids, Iron, Selenium, and Marine Hydrolyzed Collagen in Subjects With Hair Loss: A Prospective, Randomized, 3-Month, Controlled, Assessor-Blinded Study

June 2023 in “ Skin Research and Technology ”

Massimo Milani, Francesca Colombo

amino acids iron selenium marine hydrolyzed collagen androgenetic alopecia AGA FAGA telogen effluvium Global Assessment Score hair loss collagen GAS

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iron →

Selenium →

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Studysummary The researchers reported that an oral supplement containing hydrolysed fish-origin collagen, taurine, cysteine, methionine, iron, and selenium significantly improved the effectiveness of anti-hair loss treatments in people with androgenic alopecia or chronic telogen effluvium after 12 weeks, compared to drug treatments alone. Our plain-language summary of this paper — not a Tressless recommendation.

The study evaluated the effectiveness and tolerability of an oral supplement containing hydrolyzed fish-origin collagen, amino acids, and micronutrients in 83 subjects with hair loss. The subjects were divided into two groups: Group A (48 subjects) received the oral supplement and a specific drug treatment, while Group B (35 subjects) received only the drug treatment. After 12 weeks, the Global Assessment Score (GAS) was higher in Group A, indicating better hair growth. Specifically, 85.4% of patients in Group A showed an increase in GAS compared to 48.6% in Group B. The supplement and the therapies were generally well tolerated, with no significant gastro-intestinal adverse effects reported in the majority of subjects.

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