Evaluation of Oxidative Stress Markers in Androgenetic Alopecia Patients

    December 2023 in “ Benha Journal of Applied Sciences ”
    Yasser E. Ibrahim, A.M. Hamed, Shahzad Ahmed, Ghada Abd El Khalik, Eman G. Behiry
    Image of study
    TLDR AGEs and their receptors play a significant role in hair loss by causing inflammation and oxidative stress.
    The review "Evaluation of oxidative stress markers in Androgenetic Alopecia Patients" explores the role of Advanced Glycation End Products (AGEs) and their receptors (RAGE) in the development of Androgenetic Alopecia (AGA), a common type of hair loss. The study reveals that AGEs and RAGE are key contributors to AGA, exacerbating hair follicle miniaturization through oxidative stress and inflammation. The activation of RAGE by AGEs triggers inflammatory responses that disrupt the follicular environment. This understanding of the molecular interactions involved in AGA opens up possibilities for new diagnostic methods and targeted treatments to reduce hair loss in affected individuals.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Melatonin a possible tool to help fight AGA hair loss.

      in Research/Science  54 upvotes 3 years ago
      Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  136 upvotes 7 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community My hair loss stack better work 🤦🏼‍♂️

      in Progress Pictures  15 upvotes 7 months ago
      The conversation is about a user starting a hair loss treatment with Dutasteride, Minoxidil, and RU58841, hoping to prevent baldness. Other users comment on the user's current hair condition and the intensity of the chosen treatment.

      community Lost density 60% all over scalp in 120 days (4months)

      in Update  10 upvotes 5 months ago
      A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

    Similar Research

    5 / 1000+ results