Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization

This study used Mendelian randomization to examine the causal links between 187 dietary exposures and non-scarring hair loss, specifically alopecia areata (AA) and androgenetic alopecia (AGA), with data from 161,625 UK Biobank participants. It identified 18 dietary factors significantly associated with hair loss. Antioxidant-rich foods like melons, onions, and tea were found to have protective effects, while croissants, goat cheese, whole milk, and especially alcohol were linked to increased risks. Alcohol consumption emerged as a significant risk factor for both AA and AGA. The study suggests that modifying dietary patterns by increasing polyphenol-rich plant foods and reducing processed carbohydrates and alcohol could complement existing hair loss therapies. Further research is needed to refine dietary recommendations and ensure their applicability across diverse populations.