Potential Causal Relationship Between Extensive Lipid Profiles and Various Hair Loss Diseases: Evidence From Univariable and Multivariable Mendelian Randomization Analyses

    April 2025 in “ Journal of Cosmetic Dermatology
    Yuhan Xie, Ruimin Bai, Landong Ren, Hengtong Fan, Huihui Tuo, Leilei Duan, Xiaolin Zhou, Chengyu Fang, Ziyan Li, Yan Zheng
    TLDR Managing lipids may help treat hair loss.
    This study investigates the potential causal relationship between lipid profiles and hair loss disorders, including alopecia areata (AA) and androgenetic alopecia (AGA), using univariable and multivariable Mendelian randomization analyses. Analyzing 983 lipid variables, the study found 56 significant causal associations, with cholesterol, HDL-C, LDL-C, triglycerides (TG), apolipoprotein A1, apolipoprotein B, and lipoprotein(a) identified as key contributors. The multivariable analysis highlighted significant associations specifically between HDL-C, TG, and AA. Sensitivity analyses confirmed the robustness of these findings, suggesting that lipid management could be a potential therapeutic target for patients with hair loss disorders.
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