Potential Causal Relationship Between Extensive Lipid Profiles and Various Hair Loss Diseases: Evidence From Univariable and Multivariable Mendelian Randomization Analyses

    April 2025 in “ Journal of Cosmetic Dermatology
    Yuhan Xie, Ruimin Bai, Landong Ren, Hengtong Fan, Huihui Tuo, Leilei Duan, Xiaolin Zhou, Chengyu Fang, Ziyan Li, Yan Zheng
    TLDR Managing lipids may help treat hair loss.
    The study explores the causal relationship between lipid profiles and hair loss disorders using Mendelian randomization analyses, examining 983 lipid variables and 4 hair loss disorders. It identifies 56 significant causal associations, with cholesterol, HDL-C, LDL-C, triglycerides, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) as key contributors. Multivariable analysis confirms significant associations between HDL-C, triglycerides, and alopecia areata (AA). The study suggests that lipid management could be a potential therapeutic target for hair loss disorders, highlighting the importance of understanding lipid metabolism in these conditions. Despite its large sample size, limitations include reliance on summary-level data and potential misclassification of hair loss types, indicating the need for further research and validation across diverse populations.
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