Treatment of Alopecia Areata with Simvastatin and Ezetimibe

December 2017 in “ The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings ”

Jessica Cervantes, Joaquín J. Jiménez, G.M. DelCanto, Antonella Tosti

alopecia areata simvastatin ezetimibe T lymphocytic infiltrates hair follicles JAK/STAT pathway CD4+/CD25+/Foxp3+ AA statins

TLDR Simvastatin/ezetimibe may help treat new cases of alopecia areata but not long-term cases.

The document discussed the potential of simvastatin/ezetimibe as a treatment for alopecia areata (AA), an autoimmune disorder marked by T lymphocytic infiltrates around hair follicles. Statins were considered promising due to their modulation of the JAK/STAT pathway. Evidence suggested that statins might be effective for acute AA but not for chronic, longstanding cases. Animal studies indicated that statin treatment increased CD4+/CD25+/Foxp3+ populations in AA-affected mice.

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Research cited in this study

4 / 4 results

research Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients

14 citations, January 2017 in “Skin appendage disorders”

Simvastatin/ezetimibe did not effectively treat severe alopecia areata and caused side effects in some patients.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations, September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

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Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

research Alopecia Areata Update

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Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

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research Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients

13 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Simvastatin/ezetimibe may help some patients with severe alopecia areata regrow hair.

research The Pattern and Clinical Profile of Alopecia Areata: Panoramic Review, Update, and Advances on Etiopathogenesis, Associated Factors, Diagnosis, Complications, Management, and Prognosis in Treatment 2023

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Alopecia areata causes sudden hair loss, has genetic links, and can be managed but not cured.

research Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases

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New understanding and treatments for hair loss are improving, but more research is needed.

research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies

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Animal models have helped understand hair loss from alopecia areata and find new treatments.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

Treatment of Alopecia Areata with Simvastatin and Ezetimibe

Research cited in this study

research Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

research Alopecia Areata Update

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