Elucidating Causal Relationships of Diet-Derived Circulating Antioxidants and the Risk of Non-Scarring Alopecia: A Mendelian Randomization Study

This Mendelian randomization study analyzed data from over 377,200 individuals to investigate the causal relationship between diet-derived circulating antioxidants and non-scarring alopecia (AGA and AA). The study found that higher levels of β-carotene were associated with a 76% lower risk of AGA, and α-tocopherol (vitamin E) was protective against both AGA and AA. No significant associations were found for ascorbate, lycopene, or retinol. The results suggest that dietary antioxidants, particularly β-carotene and α-tocopherol, could play a crucial role in preventing hair loss, though further research is needed to validate these findings.