TLDR Mild oxidative stress can prevent hair loss from chemotherapy.
Chemotherapy often causes hair loss, leading to significant psychosocial trauma for patients. While scalp cooling can help, its effectiveness varies. This study in rats demonstrates that subcutaneous injections of hydrogen peroxide and cumene hydroperoxide can completely prevent hair loss from various chemotherapy classes. The peroxides induce cell cycle arrest through P53 activation, protecting hair follicles from chemotherapy's cytotoxic effects. This method could offer an effective and accessible way for cancer patients to preserve their quality of life during treatment.
5 citations,
March 2022 in “Frontiers in Medicine” 25 citations,
March 2018 in “Journal of oncology practice” Scalp cooling is an effective and safe way to prevent hair loss from chemotherapy, with manageable side effects and low risk of scalp cancer.
3 citations,
May 2017 in “Heliyon” Wound healing can help prevent hair loss from chemotherapy in young rats by increasing interleukin-1β signaling.
58 citations,
February 2017 in “Journal of Investigative Dermatology” Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.
48 citations,
August 2010 in “PubMed” Chemotherapy often causes hair loss, which is distressing for many, but usually reversible.
155 citations,
March 2009 in “Seminars in Cutaneous Medicine and Surgery” Scalp cooling might reduce hair loss from chemotherapy, but evidence is weak and other treatments are being tested.
1 citations,
November 2022 in “JAAD case reports” Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.
5 citations,
January 2020 in “Journal of Dermatology” Temporal hair loss relates to overall scalp hair loss in women.
41 citations,
December 2008 in “International Journal of Dermatology” South Korean women with hair loss have lower hair density and thickness compared to healthy women.
