Wound Healing Protects Against Chemotherapy-Induced Alopecia in Young Rats via Up-Regulating Interleukin-1β-Mediated Signaling

    May 2017 in “ Heliyon
    Olivera Stojadinovic, Tongyu C. Wikramanayake, Alexandra C. Villasante Fricke, Natalie Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M. Ansell, Ralf Paus, Joaquin J. Jimenez
    Image of study
    TLDR Wound healing can help prevent hair loss from chemotherapy in young rats by increasing interleukin-1β signaling.
    In a study conducted in 2017, researchers discovered that wound healing can protect against chemotherapy-induced alopecia (hair loss) in young rats. This protection was linked to the up-regulation of interleukin-1β (IL-1β), a proinflammatory cytokine. The study involved 100 neonatal rats divided into 10 groups. The researchers found that skin wounding significantly increased IL-1β signaling, which was both necessary and sufficient for protecting against hair loss caused by chemotherapy. When IL-1β was administered alone to unwounded rats, it provided local protection against hair loss, while neutralizing IL-1β removed the protection provided by wounding. The study concluded that wound healing changes the skin's cytokine environment to an IL-1β-dominated state, slowing hair follicle growth progression and making the hair follicles resistant to chemotherapy agents.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 42 results

      community Hair greed made me switch to Dut too early

      in Chat  42 upvotes 3 weeks ago
      The user switched from finasteride to dutasteride for hair loss but faced increased shedding and anxiety, regretting not staying with finasteride longer. Other users shared mixed experiences, advising patience with dutasteride, as it may take up to a year to show results.

    Related Research

    4 / 4 results