Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner

April 2014 in “ Anti-Cancer Drugs ”

Ranjitha Katikaneni, Tulasi Ponnapakkam, Andrew Seymour, J. Sakon, Robert C. Gensure

parathyroid hormone collagen binding domain PTH-CBD chemotherapy-induced alopecia hair follicle synchronization hair follicle dystrophy quiescent phase bone mineral density PTH CBD

TLDR A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.

In a study from 2014, researchers examined the effects of a fusion protein, PTH-CBD, on hair loss and bone mineral density in 42 female C57BL/6J mice undergoing chemotherapy-induced alopecia. The mice were treated with different doses of PTH-CBD (100, 320, and 1000 mcg/kg) after hair follicle synchronization. The results indicated that PTH-CBD treatment led to dose-dependent improvements in hair regrowth and reduced hair follicle dystrophy caused by chemotherapy. The highest dose of PTH-CBD also resulted in hair follicles entering a quiescent phase and increased bone mineral density to levels comparable to or higher than the control group, without significant changes in serum calcium levels. The study concluded that PTH-CBD could be a potential treatment for chemotherapy-induced alopecia and bone loss, suggesting the need for further research on topical administration and improved collagen binding.

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