Parathyroid Hormone Linked to a Collagen Binding Domain Promotes Hair Growth in a Mouse Model of Chemotherapy-Induced Alopecia in a Dose-Dependent Manner

August 2014 in “ Anti-Cancer Drugs ”

Ranjitha Katikaneni, Tulasi Ponnapakkam, Andrew Seymour, J. Sakon, Robert C. Gensure

parathyroid hormone collagen binding domain PTH-CBD chemotherapy-induced alopecia hair follicle synchronization hair follicle dystrophy quiescent phase bone mineral density PTH CBD

TLDR A hormone linked to collagen helps hair grow back in mice after chemotherapy, and may also prevent bone loss.

In a study from 2014, researchers examined the effects of a fusion protein, PTH-CBD, on hair loss and bone mineral density in 42 female C57BL/6J mice undergoing chemotherapy-induced alopecia. The mice were treated with different doses of PTH-CBD (100, 320, and 1000 mcg/kg) after hair follicle synchronization. The results indicated that PTH-CBD treatment led to dose-dependent improvements in hair regrowth and reduced hair follicle dystrophy caused by chemotherapy. The highest dose of PTH-CBD also resulted in hair follicles entering a quiescent phase and increased bone mineral density to levels comparable to or higher than the control group, without significant changes in serum calcium levels. The study concluded that PTH-CBD could be a potential treatment for chemotherapy-induced alopecia and bone loss, suggesting the need for further research on topical administration and improved collagen binding.

View this study on journals.lww.com →

Discuss this study in the Community →

Cited in this study

4 / 4 results

research Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

20 citations , January 2014 in “Anti-Cancer Drugs”

PTH-CBD could help prevent and treat hair loss caused by chemotherapy in mice.

research Tuning Wnt Signals for More or Fewer Hairs

39 citations , January 2013 in “Journal of Investigative Dermatology”

Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.

research Chemoprevention of Doxorubicin-Induced Alopecia in Mice by Dietary Administration of L-Cystine and Vitamin B6

11 citations , June 2012 in “Archives of Dermatological Research”

L-cystine and vitamin B6 at high doses prevented hair loss in mice treated with a chemotherapy drug.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , July 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

8 / 8 results

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

August 2014 in “Journal of clinical & experimental dermatology research”

Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.

research Hair Disorders Associated With Anticancer Agents

November 2013

Some cancer treatments cause different types of hair loss, but scalp cooling can help prevent it.

research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

24 citations , November 2013 in “Trends in pharmacological sciences”

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , February 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.