Transcription Factor FOXC1 Positively Regulates SFRP1 Expression in Androgenetic Alopecia

    May 2021 in “ Experimental Cell Research ”
    Lan-Bo Zhou, Qian Cao, Qi Ding, Weiling Sun, Zhiyu Li, Min Zhao, Xuewen Lin, Guo-Ping Zhou, Weixin Fan
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    TLDR FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.
    A study conducted in China found that the FOXC1 transcription factor positively regulates SFRP1 expression in androgenetic alopecia (AGA), which could lead to new treatment options for the condition. The study used various methods such as immunofluorescence, chromatin immunoprecipitation, and quantitative real-time PCR to investigate the regulation of SFRP1 promoter in AGA. The study found that FOXC1 can increase the expression of SFRP1 in dermal papilla cells in AGA patients, indicating that it could be a potential target for hair loss treatments.
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