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Secreted Frizzled-Related Protein 2

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Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

research Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

68 citations , May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

research Transcription Factor FOXC1 Positively Regulates SFRP1 Expression in Androgenetic Alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

research Double Knockdown of DKK1 and SFRP1, Two Key Players in Androgenetic Alopecia, Does Not Accelerate the Hair-Growth Promoting Effect of Individual SFRP1 Knockdown in Healthy Human Hair Follicles Ex Vivo

July 2025 in “Journal of Investigative Dermatology”

research Silencing Key Players of Androgenetic Alopecia Pathogenesis in Healthy Human Hair Follicles Ex Vivo Highlights the Hair Growth Inhibitory Effect of SFRP1

September 2025 in “Journal of the American Academy of Dermatology”

research Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

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community Starting Way-316606 for the first time today.

in Research/Science 30 upvotes 6 months ago

A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 6 months ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community The DEFINITIVE cure for hairloss

in Satire 270 upvotes 3 months ago

The conversation humorously suggests using immunosuppressants like ciclosporine and oral minoxidil for hair regrowth, with a satirical plan involving hair transplants from family members. It highlights the side effects and impracticality of such treatments, emphasizing the post's satirical nature.

community find a cure for this shit already

in Chat 208 upvotes 4 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.