Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

March 2014 in “ Journal of The European Academy of Dermatology and Venereology ”

R. Kucerova, M. Bienova, Michal Král, Jan Bouchal, Katerina Smesny Trtkova, Alena Burdova, Vladimír Študent, Zdenek Kolar

androgenetic alopecia benign prostatic hyperplasia prostate cancer androgen receptor gene SNP rs6152 AR gene polymorphism G allele PSA androgen-dependent disorders AGA BPH CaP AR gene single nucleotide polymorphism prostate-specific antigen

Studysummary In this study, researchers found that androgen receptor gene polymorphism is associated with higher androgenetic alopecia grades and PSA levels in men with benign prostatic hyperplasia, but not with prostate cancer.

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research Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis

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This meta-analysis suggests that the G allele of AR StuI polymorphism might be a potential risk factor for AGA, particularly in white populations.

research Male Pattern Baldness and the Risk of Prostate Cancer

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This study found that early-onset androgenic alopecia is associated with a higher risk of developing prostate cancer, although it was not linked to earlier diagnosis or more aggressive tumors.

research Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer

28 citations , June 2010 in “European Journal of Cancer”

This study found that androgenic alopecia at an early age was associated with a lower risk of prostate cancer, contrary to assumptions about androgens' role.

research Male Pattern Baldness and Prostate Cancer Risk in a Population-Based Case-Control Study

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research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

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This abstract contains only supplementary material information and reports no new research findings.

research Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels

30 citations , January 2008 in “The Aging Male”

This study found no difference in male pattern baldness between patients with benign prostate hyperplasia and prostate cancer, and no correlation with serum androgen levels.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations , January 2007 in “Human Genetics”

In this study, researchers found that while the SNP rs6152 is strongly associated with androgenetic alopecia, the GGN triplet repeat is not, suggesting the causative variant is likely a non-coding one.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

76 citations , April 2005 in “Cancer Epidemiology, Biomarkers & Prevention”

This study found that the AR-E211 A allele is associated with a lower risk of both metastatic prostate cancer and androgenetic alopecia in an Australian population.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations , August 2002 in “Experimental Gerontology”

This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

research Androgenetic Alopecia and Microinflammation

131 citations , August 2000 in “International Journal of Dermatology”

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

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This article reviews common hair disorders and their normal anatomy and life cycle, but reports no new research findings.

research The Biology of Hair Follicles

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research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.