Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

January 2015 in “ Journal of The European Academy of Dermatology and Venereology ”

R. Kucerova, M. Bienova, Michal Král, Jan Bouchal, Katerina Smesny Trtkova, Alena Burdova, Vladimír Študent, Zdenek Kolar

TLDR Hair loss gene linked to prostate issues.

This study investigated the relationship between androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH), and prostate cancer (CaP) with the androgen receptor gene polymorphism (SNP rs6152). The study found a significant association between the SNP rs6152 and AGA, BPH, and CaP. The results suggest that the AR gene polymorphism may play a role in the development of androgen-dependent disorders. The study also found a significant relationship between the AR gene polymorphism and AGA progression, with the predominant G allele being more frequent in patients with higher grade of alopecia and significantly associated with higher PSA. However, the relationship between inflammation and AGA needs to be verified by another study.

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