The Potential of Resveratrol-Rich Peanut Callus Extract in Promoting Hair Growth and Preventing Hair Loss

August 2024 in “ Cosmetics ”

Wannisa Vichit, Nisakorn Saewan

resveratrol peanut callus extract human dermal papilla cells hDPCs oxidative damage growth factor expression 5α-reductase inhibition anagen/telogen ratio peanut extract dermal papilla cells hair growth factors 5-alpha reductase inhibition

Studysummary This study reported that peanut callus extract, rich in resveratrol, significantly stimulated hair growth and reduced hair loss in an in vitro model and a clinical trial, showing promise as a cosmetic bioactive ingredient.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study evaluated the potential of resveratrol-rich peanut callus extract in promoting hair growth and preventing hair loss. It involved 60 participants with mild to moderate alopecia, divided into placebo, 15% peanut callus extract, and 0.5% resveratrol groups over 12 weeks. The peanut callus extract group showed significant improvement in hair growth and reduction in hair loss, attributed to its high resveratrol content (191.97 ppm), which promoted hDPCs proliferation, inhibited 5α-reductase, and increased growth factors (IGF-1, KGF, HGF, VEGF). The extract also provided protection against oxidative stress and inflammation. The findings suggest that peanut callus extract is a promising natural ingredient for hair loss treatments.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

This review examines the efficacy of various novel treatments for androgenetic alopecia, including oral minoxidil and platelet-rich plasma, suggesting potential benefits but emphasizing the need for further high-quality clinical trials to thoroughly evaluate their effectiveness.

Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells

research Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells

3 citations , September 2022 in “Molecules”

This study found that Camellia seed cake extract may counteract DHT-induced effects in cultured dermal papilla cells, suggesting potential to prevent or alleviate androgenetic alopecia.

research Effect of Coffee Berry Extract on Anti-Aging for Skin and Hair: In Vitro Approach

8 citations , June 2022 in “Cosmetics”

This study found that coffee berry extract demonstrated anti-aging properties in skin and hair cells, showing significant anti-collagenase activity and stimulating hair-related gene expression, suggesting its potential for use in cosmeceuticals.

research Modulation of Hair Growth Promoting Effect by Natural Products

7 citations , December 2021 in “Pharmaceutics”

This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.

research Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells

11 citations , November 2021 in “Clinical, Cosmetic and Investigational Dermatology”

This study found that resveratrol promoted hair growth in mice and human hair follicles, suggesting its potential as a treatment for hair loss.

research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.

research Physcion, a Novel Inhibitor of 5α-Reductase That Promotes Hair Growth In Vitro and In Vivo

18 citations , February 2021 in “Archives of Dermatological Research”

This study found that Physcion from Polygonum multiflorum may be an effective natural 5α-reductase inhibitor for treating androgenic alopecia by enhancing hair growth and improving follicle morphology in laboratory settings.

research Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

29 citations , January 2021 in “Journal of Investigative Dermatology”

This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.

research Multiple Potential Roles of Thymosin Beta 4 in the Growth and Development of Hair Follicles

13 citations , January 2021 in “Journal of Cellular and Molecular Medicine”

This review discusses the roles and mechanisms of thymosin β4 in hair follicle growth and development but reports no new experimental findings; the authors emphasize the need for further research on its molecular pathways.

research A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit

26 citations , December 2020 in “Genes”

This study found that a combination of insulin-like growth factor-1 and epidermal growth factor significantly promoted hair follicle growth and development in both cultured hair follicles and rabbits.

research Fisetin Promotes Hair Growth by Augmenting TERT Expression

22 citations , October 2020 in “Frontiers in Cell and Developmental Biology”

This study found that resveratrol and fisetin promoted hair growth in mice by inducing telomerase reverse transcriptase expression, which activates hair follicle stem cells and transitions follicles from a resting to a growth phase.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations , September 2020 in “Molecules”

In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.

research Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall

14 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

This study found that a hair serum containing amla extract, freeze-dried coconut water, and selenium significantly improved hair growth rate, density, and reduced hair fall among healthy volunteers over 90 days.

research A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers

8 citations , January 2020 in “International Journal of Cosmetic Science”

This study found that applying a combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol significantly increased hair density in Caucasian women after 1.5 months, potentially due to their synergistic effect on the HIF‐1α pathway.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.

research The Effect of Lactobacillus Plantarum Hydrolysates Promoting VEGF Production on Vascular and Hair Growth in C57BL/6 Mice

10 citations , April 2019 in “Journal of Analytical Science and Technology”

In this study, hydrolysates of lactic acid bacteria were found to enhance hair growth in C57BL/6 male mice more effectively than 5% minoxidil.

research The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia

6 citations , January 2019 in “Journal of lasers in medical sciences”

This study found that using a fractional CO2 laser in combination with minoxidil significantly increased hair count and thickness in Egyptian men with androgenetic alopecia.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

research Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

29 citations , August 2017 in “Skin appendage disorders”

This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.