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research Sponsored Lecture 3 : Updates on 5 alpha-rers(5ARIs) for the treatment of male pattern hair loss(MPHL)

January 2014 in “프로그램북(구 초록집)”

This article reviews updates on 5 alpha-reductase inhibitors for treating male pattern hair loss and presents no new clinical findings; the author aims to enhance understanding of these therapies.

Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia

research Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia

14 citations , November 2006 in “Current Medicinal Chemistry”

This review discusses recent developments in α1-adrenoceptor antagonists and 5α-reductase inhibitors for treating benign prostatic hyperplasia, reporting no new clinical results while identifying potential areas for future drug development.

Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride

25 citations , September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.

research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments

48 citations , January 2011 in “Neuropharmacology”

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase

29 citations , July 2009 in “BJU international”

This review examines the pharmacological properties and potential clinical benefits of 5α‐reductase inhibition in prostate cancer but reports no new research findings.

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community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 3 years ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Age 18 vs Age 25, the importance of starting early

886 upvotes 1 year ago

An 18-year-old began using Finasteride and Topical Minoxidil for hair loss, later switching to Oral Minoxidil and Dutasteride by age 25. The conversation emphasizes early treatment, potential side effects, and differing opinions on medication effectiveness.

community Has anyone ever used grape seed extract? Any negative effects on hair ?

4 upvotes 5 years ago

The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.

community Long time users of Dut/Fin, what would you do differently if you had to start all over?

23 upvotes 1 year ago

People shared experiences with hair loss treatments like Minoxidil, Finasteride, and Dutasteride. Opinions varied on effectiveness and side effects, with advice to start early and adjust dosages based on individual reactions.

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