Bioactive Inorganic Particles-Based Biomaterials for Skin Tissue Engineering

The document reviewed the potential of bioactive inorganic particles-based biomaterials in skin tissue engineering, particularly for wound healing and skin regeneration. It highlighted the use of materials like bioglass, silica-based particles, metal/metal oxide nanoparticles, and carbon-based materials, which demonstrated properties such as hemostasis, angiogenesis, immunoregulation, antibacterial effects, and promotion of hair follicle regeneration. These materials were often combined with organic polymers to create composite scaffolds that enhance skin repair. The review emphasized the importance of matching the degradation rate of these materials with skin regeneration and discussed challenges like mechanical property mismatches and toxicity. Future research aimed to develop "smart" materials with multiple biofunctions and improve biocompatibility for successful clinical application.