Lidocaine-Loaded Solid Lipid Microparticles Produced from Gas-Saturated Solutions for Wound Applications

The study developed lidocaine-loaded solid lipid microparticles (SLMPs) using the PGSS technique for wound applications, achieving high encapsulation efficiency and tunable lidocaine content. These SLMPs showed a sustained release of lidocaine, with 50% released after 4 hours and complete release after 24 hours, fitting a first-order kinetic model. They demonstrated significant antimicrobial activity against bacteria like E. coli, S. aureus, and P. aeruginosa, suggesting potential for reduced dosing and extended local anesthesia duration compared to traditional formulations. The study confirmed the non-toxicity of the particles using 3D-bioprinted skin models, highlighting their potential for combined anesthetic and antimicrobial effects in chronic wound management.