Lidocaine-Loaded Solid Lipid Microparticles Produced from Gas-Saturated Solutions for Wound Applications

This study focused on the development of lidocaine-loaded solid lipid microparticles (SLMPs) for wound applications, using a solvent-free PGSS technique with supercritical CO2. The SLMPs, made from glyceryl monostearate and containing varying lidocaine concentrations (up to 10 wt.%), were evaluated for their drug delivery capabilities and antimicrobial activity. Characterization included assessments of shape, size, morphology, and drug release behavior. In vitro tests using 3D-bioprinted human skin substitutes demonstrated that SLMPs with 10 wt.% lidocaine effectively delivered pain relief and exhibited antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, indicating their potential for improved wound treatment.