Porous Gradient Hydrogel Promotes Skin Regeneration by Angiogenesis
October 2024
in “
Journal of colloid and interface science
”
bilayer bionic skin scaffold methacrylated sericin protein tannic acid dopamine antioxidant capabilities cell proliferation cell migration antimicrobial properties pro-angiogenic properties collagen deposition neovascularization hair follicle formation bionic skin scaffold sericin protein antioxidants cell growth new blood vessels hair growth
TLDR The hydrogel helps skin heal by encouraging new blood vessel growth.
The study developed a bilayer bionic skin scaffold (Bilayer SF) using methacrylated sericin protein to mimic the skin's multilayered structure. The outer layer (SF@TA) resists bacterial invasion with a small pore structure and tannic acid crosslinking, while the inner layer (SF@DA@Gel) promotes cellular growth with a large pore structure and dopamine. The scaffold demonstrated good mechanical properties, antioxidant capabilities, and promoted cell proliferation and migration. In vitro studies confirmed its antimicrobial and pro-angiogenic properties. In vivo animal studies showed that the scaffold enhanced collagen deposition, neovascularization, and marginal hair follicle formation, indicating its potential as a new bionic skin scaffold.
