Construction of Large-Scale Bioengineered Hair Germs and In Vivo Transplantation

    March 2025 in “ Advanced Science ”
    Yangpeng Chen, Yuhui Hou, Jiejian Chen, Jiaojiao Bai, Lijuan Du, Chen Qiu, Hanzhou Qi, Xuanbei Liu, Junfei Huang
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    Studysummary In this study, bioengineered hair germ microspheres made from HME hydrogels promoted hair follicle regeneration in vivo, suggesting a promising approach for hair loss treatment.
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    The study successfully developed large-scale bioengineered hair germs (BHGs) using a novel coaxial-flow microfluidic system, which encapsulates Wnt3a in dual-layered microspheres to promote hair follicle regeneration. The system utilizes HME hydrogels and GelMA to provide a supportive scaffold, ensuring consistent encapsulation and sustained Wnt3a release. In vivo experiments on BALB/c nude mice demonstrated that these BHGs led to a higher number of regenerated hair germs and reduced inflammation compared to traditional methods. The study highlights the potential of this system for clinical applications in treating hair loss conditions such as alopecia, although further research is needed to assess long-term efficacy and safety.
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