Bioengineering of Hair Follicle-Like Structure for Validation of Hair Growth Promoting Compounds

November 2022 in “ Bioengineering ”

Hyun Woo Joo, Min Kyu Kim, Soon Sun Bak, Young Kwan Sung

hair follicle-like structure HFLS dermal papilla cells keratinocyte cell line minoxidil tofacitinib ascorbic acid Rogaine Vitamin C

TLDR The method can test hair growth products using a lab-made hair-like structure that responds to known treatments.

The study developed a method for testing hair growth promoting agents by creating a hair follicle-like structure (HFLS) using an immortalized cell line derived from dermal papilla cells and a neonatal foreskin-derived keratinocyte cell line. The HFLS was treated with three known hair growth promoting compounds: minoxidil, tofacitinib, and ascorbic acid. The results showed a significant increase in the elongation of the HFLS upon treatment with these compounds, suggesting this method could be used for screening and evaluating hair care materials. The number of HFLS in each group ranged from 46 to 98 individual structures.

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