Novel PLCL Nanofibrous/Keratin Hydrogel Bilayer Wound Dressing for Skin Wound Repair

In this study, researchers developed a biopolymer-based dual-layer wound dressing that significantly improved healing outcomes in a 14-day rat model, reporting 94% wound closure by day 15 and enhanced tissue regeneration, swelling properties, and cell viability.

This study found that a nanoparticle-in-nanofiber system significantly accelerated wound healing in rats by promoting angiogenesis and tissue regeneration more effectively than a commercial wound dressing.

This study developed a multifunctional bilayer dressing containing nanosilver and basic fibroblast growth factor, which improved wound healing by preventing bacterial penetration, promoting angiogenesis and hemostasis, and accelerating cell proliferation and migration, outperforming a control group by increasing healing rates by 47% in vivo.

In animal models, this study reported that a wound dressing combining quaternized chitin and silk fibroin significantly enhanced vascular reconstruction and hair follicle regeneration, approaching normal tissue levels.

This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.