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Glossary Dopamine

neurotransmitter involved in reward, pleasure, and movement regulation

Dopamine is a neurotransmitter, often referred to as DA or 3,4-dihydroxyphenethylamine, that plays a crucial role in the brain's reward and pleasure systems. It is also involved in regulating movement, attention, and emotional responses, and its imbalance is linked to conditions such as Parkinson's disease and schizophrenia.

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Research

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research Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation

53 citations , October 2011 in “Psychoneuroendocrinology”

Finasteride may help improve certain brain function issues linked to dopamine.

research Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output

52 citations , April 2002 in “Brain Research”

This study found that in rats, finasteride significantly reduced allopregnanolone in the cortex and increased both the rise and duration of dopamine levels in the prefrontal cortex in response to stress and anxiogenic stimuli.

research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments

48 citations , January 2011 in “Neuropharmacology”

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

research A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy

39 citations , August 2022 in “Cell Death and Disease”

This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.

research The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson’s disease

27 citations , May 2015 in “Neuropharmacology”

This study found that Dutasteride, a 5α-reductase inhibitor, demonstrated neuroprotective effects by preventing the MPTP-induced decline of dopaminergic markers in a Parkinson's disease mouse model.

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community Any adderall / vyvanse users here?

1 upvotes 6 months ago

Adderall and Vyvanse may contribute to hair loss by stressing the dopamine system and increasing cortisol levels. Users discuss potential treatments like Minoxidil, finasteride, and RU58841 for managing hair loss.

community Has anyone with high prolactin taken meds to lower it and seen hair regrowth?

5 upvotes 8 months ago

High prolactin levels may contribute to hair loss, and some users suggest supplements like mucuna pruriens, vitamin B6, vitamin E, L-Tyrosine, L-Theanine, DIM, and Zinc to lower prolactin. Lifestyle changes to increase dopamine, such as reducing screen time and stress, are also recommended.

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