Particle-Based Transcutaneous Administration of HIV-1 p24 Protein to Human Skin Explants and Targeting of Epidermal Antigen Presenting Cells

January 2014 in “ Journal of Controlled Release ”

Fiorenza Rancan, Sarah Amselgruber, Sabrina Hadam, Séverine Munier, Vincent Pavot, Bernard Verrier, Steffen Hackbarth, Béhazine Combadière, Ulrike Blume‐Peytavi, Annika Vogt

Studysummary This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.

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