In Vivo Penetration of Bare and Lipid-Coated Silica Nanoparticles Across the Human Stratum Corneum

    August 2014 in “ Colloids and surfaces. B, Biointerfaces ”
    Valentina Iannuccelli, Davide Bertelli, Marcello Romagnoli, Santo Scalia, Eleonora Maretti, Francesca Sacchetti, Eliana Grazia Leo
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    TLDR Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.
    The study examined the penetration of two types of silica nanoparticles (NPs) through the human stratum corneum (SC): bare hydrophilic silica (B-silica) and hydrophobic lipid-coated silica (LC-silica). It involved 5 healthy Caucasian volunteers (3 female and 2 male, aged 20-62). The NPs were applied to the forearms and analyzed using tape stripping, Energy Dispersive X-ray (EDX) analysis, and Inductively Coupled Plasma quadrupole Mass Spectrometry (ICP-MS). The study found that only about 10% of B-silica penetrated the deepest SC layers, while LC-silica showed greater penetration (about 42% on the volar forearm and 18% on the dorsal forearm). The results indicated that NP surface polarity significantly affects skin penetration more than size, with hydrophobic LC-silica penetrating deeper into the SC. The study concluded that the hydrophilic character of silica NPs causes retention in the superficial SC layers, and hair follicle density does not significantly affect penetration, suggesting that the transfollicular route is not a major pathway for NP penetration within the examined size range.
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