Polystyrene-b-Poly (Acrylic Acid) Nanovesicles Coated by Modified Chitosans for Encapsulation of Minoxidil

    January 2022 in “ Brazilian Journal of Pharmaceutical Sciences ”
    Gilmar Hanck-Silva, Edson Minatti
    TLDR Minoxidil can be effectively encapsulated in coated nanovesicles for potential drug delivery.
    This study investigated the encapsulation of minoxidil in polystyrene-b-poly(acrylic acid) (PS-b-PAA) nanovesicles coated with chemically modified chitosans. The nanovesicles, produced using an organic cosolvent method, had diameters under 150 nm and a negative zeta potential, which changed to positive after coating. The encapsulation efficiency of minoxidil was approximately 50%, indicating potential as drug delivery carriers. The study confirmed the successful coating and stabilization of nanovesicles through dynamic light scattering (DLS), zeta potential measurements, and transmission electron microscopy (TEM). The removal of residual organic solvent was more effective with dialysis than evaporation. Future research will focus on further characterization and testing of these systems.
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