Recent Advances in Microneedle Composites for Biomedical Applications: Advanced Drug Delivery Technologies

May 2019 in “ Materials Science and Engineering: C ”

Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Sainath Sindhikar, Dinesh Kumar Mishra

microneedle drug delivery cosmetic treatments therapeutic drug delivery solid microneedles hollow microneedles coated microneedles dissolving microneedles hydrogel-forming microneedles skin penetration MN

Studysummary This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The document from 2019 provides a comprehensive overview of microneedle (MN) technology advancements in drug delivery, diagnostics, therapeutics, and cosmetics from 2000 to 2019. MNs are minimally invasive tools that improve drug permeability and patient compliance, and are effective for vaccinations, cosmetic treatments, and therapeutic drug delivery. Various types of MNs, such as solid, hollow, coated, dissolving, and hydrogel-forming, are discussed along with their materials and fabrication methods. The review also addresses challenges like dose accuracy, skin penetration variability, and the need for more clinical data for widespread use. Clinical studies cited demonstrate MNs' effectiveness in delivering insulin, pain management, and cosmetic applications. Despite the potential and increasing popularity of MNs, further research and development are required to overcome challenges and optimize their applications in healthcare.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

research Microneedles as the Technique of Drug Delivery Enhancement in Diverse Organs and Tissues

140 citations , December 2017 in “Journal of Controlled Release”

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

research Microneedle Applications in Improving Skin Appearance

131 citations , May 2015 in “Experimental Dermatology”

This review explores the development and cosmeceutical applications of microneedles for skin treatment, without reporting new clinical results, emphasizing safety and public perception as key factors for commercialization.

research Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy

68 citations , May 2015 in “Indian Journal of Dermatology”

This case series found that adding microneedling to conventional finasteride and minoxidil therapy for androgenetic alopecia improved new hair growth and patient satisfaction in poor responders.