Recent Advances in Microneedle Composites for Biomedical Applications: Advanced Drug Delivery Technologies

    May 2019 in “ Materials Science and Engineering: C ”
    Sanjay Sharma, Ketan Hatware, Prashant Bhadane, Sainath Sindhikar, Dinesh Kumar Mishra
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    TLDR Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.
    The document from 2019 provides a comprehensive overview of microneedle (MN) technology advancements in drug delivery, diagnostics, therapeutics, and cosmetics from 2000 to 2019. MNs are minimally invasive tools that improve drug permeability and patient compliance, and are effective for vaccinations, cosmetic treatments, and therapeutic drug delivery. Various types of MNs, such as solid, hollow, coated, dissolving, and hydrogel-forming, are discussed along with their materials and fabrication methods. The review also addresses challenges like dose accuracy, skin penetration variability, and the need for more clinical data for widespread use. Clinical studies cited demonstrate MNs' effectiveness in delivering insulin, pain management, and cosmetic applications. Despite the potential and increasing popularity of MNs, further research and development are required to overcome challenges and optimize their applications in healthcare.
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