Nanocrystals of Medium Soluble Actives: Novel Concept for Improved Dermal Delivery and Production Strategy

    May 2014 in “ International journal of pharmaceutics ”
    Xuezhen Zhai, Jürgen Lademann, Cornelia M. Keck, Rainer H. Müller
    Studysummary This research describes a process for producing caffeine nanocrystals, which may enhance skin penetration by accumulating in hair follicles and maintaining stability for two months, paving the way for in vivo testing.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    2. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    3. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    4. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
    5. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    6. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004