Dermal Nanocrystals from Medium Soluble Actives: Physical Stability and Stability Affecting Parameters
September 2014
in “
European journal of pharmaceutics and biopharmaceutics
”
TLDR Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.
The study from 2014 focused on the production and stability of caffeine nanocrystals, aiming to enhance dermal penetration for medium soluble drugs. It was found that the stability of these nanocrystals was significantly influenced by the choice of stabilizer and the dispersion medium. Carbopol® 981 emerged as an effective stabilizer, maintaining nanocrystal size at 4 °C and 25 °C over two months, although all formulations showed size increase at 40 °C due to higher solubility and Ostwald ripening. The study concluded that the physical stability of caffeine nanosuspensions was promising for in vivo studies and could potentially improve the performance of dermal anti-cellulite products. The research was supported by The China Scholarship Council for the first author.
