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This study reported that larger caffeine nanocrystals, at 694 nm, increased caffeine bioavailability via transfollicular penetration compared to smaller nanocrystals, especially in long-term serum concentration measurements.

This study established a stable formulation for caffeine nanocrystals in specific solvent mixtures, which could be used to test their potential for enhanced hair follicle targeting and penetration.

This study reported that ultrafine gelatin nanoparticles produced by a modified desolvation technique offer advantages for dermal drug delivery, including smaller particle size, higher drug loading, and faster release compared to traditional gelatin nanoparticles.

This research describes a process for producing caffeine nanocrystals, which may enhance skin penetration by accumulating in hair follicles and maintaining stability for two months, paving the way for in vivo testing.

This study reported that combining microdialysis and selective follicular closure with varnish significantly reduces caffeine penetration through hair follicles in an ex vivo porcine ear skin model.